Michigan dominated Saint Louis with a 95-72 victory, advancing to its 16th Sweet 16 appearance. Yaxel Lendeborg led the Wolverines with 25 points and became the first Michigan player to achieve that milestone without turnovers since Glen Rice in 1989. Michigan's 55.7% shooting and stifling defense forced the Billikens into difficult shots.

The Wolverines set a program record with nine blocks, their most in an NCAA tournament game since blocks were first tracked in 1985-86. Michigan completely controlled the glass, outrebounding Saint Louis 42-27. Billikens center Robbie Avila struggled from the perimeter but received "Robbie" cheers from fans as he left the court with five assists.

This victory marks a historic achievement for Michigan as the first Big Ten team to record consecutive NCAA tournament games with 90-plus points since their 1989 championship team. The Wolverines' offensive firepower and defensive prowess position them as serious contenders in the tournament.