Pekan 22 memulai playoff fantasy baseball di liga head-to-head standar ESPN, total 97 pertandingan — paling banyak dalam periode skor 7 hari musim ini. 14 tim main 7 pertandingan, 10 dari American League. Semifinal berlangsung 2 pekan, pemenang lolos ke babak final mulai 14 September. Perluasan roster MLB mulai Selasa, 1 September, mengizinkan tim bawa 28 pemain (maks. 14 pitcher), membuka peluang prospek seperti Franklin Arias, Ralphy Velazquez, Charlie Condon, Josue De Paula, dan Coleman Crow. Boston Red Sox tetap di perebutan wild card AL, hadapi Seattle Mariners dan Baltimore Orioles. Arizona Diamondbacks nunggu Ketel Marte pulang sambil berebut wild card NL. Colorado Rockies dapet seri rumah yang menguntungkan lawan Baltimore Orioles dan St. Louis Cardinals.

Perebutan divisi makin sengit: Milwaukee Brewers rumah lawan Chicago Cubs, Chicago White Sox lawan Minnesota Twins, Atlanta Braves lawan Philadelphia Phillies. Manajer fantasy bisa set lineup Pekan 23 Senin, 7 September.