Week 22 kicks off the fantasy baseball playoffs in ESPN standard head-to-head leagues, featuring 97 total games — the most in a seven-day scoring period this season. Fourteen teams play seven games, with 10 from the American League. The semifinals span two weeks, with winners advancing to the championship round starting Sept. 14.

MLB roster expansion begins Tuesday, Sept. 1, allowing teams to carry 28 players (maximum 14 pitchers), opening opportunities for prospects like Franklin Arias, Ralphy Velazquez, Charlie Condon, Josue De Paula, and Coleman Crow. The Boston Red Sox remain in the AL wild card race, facing the Seattle Mariners and Baltimore Orioles. The Arizona Diamondbacks await Ketel Marte's return while competing in the NL wild card chase.

The Colorado Rockies enjoy a favorable home stand against the Baltimore Orioles and St. Louis Cardinals. Divisional races intensify as the Milwaukee Brewers host the Chicago Cubs, the Chicago White Sox face the Minnesota Twins, and the Atlanta Braves battle the Philadelphia Phillies. Fantasy managers can set Week 23 lineups on Monday, Sept. 7.