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Last updated: October 17, 2026, 4:20 PM ET

Week 6 Previews and Predictions

Fantasy managers facing bye weeks and injuries have plenty of options, with Adam Rank naming six quarterbacks worth adding before kickoff. Our experts also weighed the odds and player props for Sunday's slate, while a full game-by-game guide breaks down every matchup, from Mahomes against Herbert to Stroud against Lawrence. Waiver-wire help is covered in last-minute pickups, where Winston and Tucker lead the list.

Injuries and Lineup News

The Eagles face their most serious setback, as Jalen Hurts has been ruled out against the Panthers with a blood clot in his calf, and sources say the team is not planning to place him on injured reserve. Philadelphia's backfield is also thin, with Saquon Barkley ruled out Sunday. In Baltimore, Lamar Jackson is out for a second straight week, which puts Huntley in line to start against the Browns. Kansas City loses its top receiver as Rashee Rice sits with a hamstring injury, while Cleveland gets good news as KC Concepcion cleared the concussion protocol. New England is expected to get a boost when A.J. Brown is activated for the Jets game, and the Jets themselves will have Omar Cooper Jr. back after an ankle issue.

Week 5 Results and Reaction

Denver held off Seattle 17-14 in overtime, with the Broncos winning on the ground behind two rushing touchdowns and a five-sack performance on defense. Seattle quarterback Sam Darnold owned up to two late interceptions, and coach Mike Macdonald is sticking with him despite seven picks in four games. In Denver, linebacker Jonathon Cooper was removed from the exempt list, though league discipline remains possible. Josh Jacobs is eligible to return to Green Bay next week, and the Jaguars' London pub crowd showed how deep the team's international fanbase runs.

Front Office and Long-Term Outlook

Tennessee's CEO Burke Nihill apologized to fans and said the organization still backs Robert Saleh and the general manager to turn things around. Jacksonville is unlikely to play three international home games in 2027. Looking further ahead, Mel Kiper's 2027 big board features seven quarterbacks in its top, and a retrospective examines how the Micah Parsons trade continues to shape both Dallas and Green Bay. Chargers running back Omarion Hampton has seen his snap count decline, with coaches explaining that there is only one ball. Aaron Rodgers is also drawing attention for his pop quizzes for Pittsburgh's young receivers as he prepares them for games.

Coming Up

Sunday's full slate is previewed in the game-by-game guide, including Kansas City against the Chargers. Jacobs is eligible to return next week, when he is removed from the commissioner exempt list.