The long-held theory that antidepressants work by correcting a serotonin imbalance is now widely questioned by researchers. Psychiatrists are exploring alternative explanations for how these drugs function. Current hypotheses suggest antidepressants may promote neuroplasticity, helping the brain form new neural connections over time.
Another theory points to anti-inflammatory effects, as depression is increasingly linked to chronic inflammation. Some researchers also emphasize the role of the gut-brain axis, noting that antidepressants can alter gut microbiome composition. The most promising models focus on how these medications might help the brain adapt and rewire itself rather than simply replenishing a deficient chemical.
This shift in understanding could lead to more targeted and effective treatments in the future.
Source: New York Times Top Stories · Summarized by HeadlinesBriefing