PSV Eindhoven striker Ricardo Pepi was substituted after just eight minutes in a match against FC Twente due to injury, raising concerns for the U.S. men's national team ahead of the FIFA international window. U.S. manager Mauricio Pochettino had included Pepi in a 28-player squad for upcoming matches against Peru, Chile, Mexico, and Canada. Pepi's early exit adds to existing absences, as Christian Pulisic and Folarin Balogun are already unavailable. Pochettino has called up 16-year-old Cavan Sullivan of the Philadelphia Union, along with Cole Campbell, Justin Ellis, and Julian Hall, to bolster the forward options.

Players were due to report for duty on Sunday, but Pepi's injury complicates selection plans. The U.S. will face Peru on Sept. 26 in Orlando, Florida, followed by Chile on Sept. 29 in St. Louis, Mexico on Oct. 3 in Glendale, Arizona, and Canada on Oct. 6 in St. Paul, Minnesota.