Major League Baseball is slated for its earliest Opening Day on March 24, 2027, with a single game to be televised by Netflix. The specific teams for this opener have not yet been determined, but a list of potential matchups across the league has been released.

This early start is contingent on the resolution of labor negotiations, as the collective bargaining agreement expires on December 1. A management lockout is anticipated, similar to the situation in 2022 which delayed Opening Day from March 31 to April 7. The league aims for the regular season to conclude on September 26, 2027.

Additionally, Wrigley Field is set to host the All-Star Game on July 13, followed by a rivalry weekend. The Athletics are expected to continue playing most home games in West Sacramento before relocating to Las Vegas. No international games are currently scheduled for 2027 due to the unresolved labor contract.