Iowa defeated Michigan 20-19 on a last-second touchdown pass from Hank Brown to Reece Vander Zee in Ann Arbor, Michigan. The Hawkeyes trailed in the final minute but completed a 91-yard drive in the closing seconds, aided by a penalty and an injury timeout. Brown connected with Vander Zee for a 16-yard score as time expired, marking Iowa's first win when trailing in the final minute in a decade.

Coach Kirk Ferentz praised the team's resilience, while Michigan's Kyle Whittingham expressed disappointment. The victory improved Iowa to 4-0 overall and 1-0 in the Big Ten, while Michigan fell to 3-1. The game was the second this season decided on the final play at the Big House.