Duke has emerged as the men's college basketball national championship favorite with +350 odds as the NCAA tournament tips off. The Blue Devils opened at +330 but have attracted heavy betting action to move to the top spot. Michigan follows closely at +370, while Arizona sits just behind at +380, making these three teams the clear frontrunners.

Among the other top seeds, Florida sits at +750 odds despite being a No. 1 seed, while Houston (13-1) and Iowa State (18-1) represent the best value among teams under 20-1. Illinois has seen its odds drift from 19-1 to 22-1, suggesting bettors are losing confidence in the Fighting Illini's title chances.

Purdue and UConn, both at longer odds of 25-1 and 30-1 respectively, have attracted significant betting interest. The Boilermakers have generated the fifth-most handle at DraftKings and landed a $100,000 wager to reach the Final Four at BetMGM. Meanwhile, UConn has drawn several large bets at both books, creating liability for sportsbooks. The betting market shows clear separation between the blue-blood programs and the field, with 19 teams sitting at 200-1 odds.