The 2026 NCAA Men's Basketball Tournament begins Tuesday and Wednesday with a series of intriguing first-round matchups featuring several heavy favorites. Duke (32-2), Michigan (31-2), and Florida (31-2) are the top seeds and are overwhelming favorites to win their opening games against Siena, Ohio State, and Texas respectively. Duke is a 20,000-to-1 longshot to win the championship, while Michigan and Florida are each around 1,000-to-1. The betting lines also highlight the stark disparity between the top seeds and their lower-ranked opponents, with projections suggesting Duke could win by 28.9 points and Michigan by 15.9 points. DraftKings Sportsbook provides these odds, which are subject to change before tip-off.