The Seattle Seahawks (2-0) improved their record with a 31-7 win over the Arizona Cardinals at State Farm Stadium. Coach Mike Macdonald indicated that quarterback Sam Darnold's glute injury recovery has "shifted quite drastically" and he could return to practice this week, possibly playing next Sunday against the Washington Commanders. In Darnold's absence, Drew Lock delivered a strong performance, completing 19 of 26 passes for 235 yards and three touchdowns, all to Jaxon Smith-Njigba. Lock's first touchdown to Smith-Njigba was an 82-yarder on their second play, and they connected again on 7‑ and 12‑yard scores. Smith-Njigba became the third Seahawks receiver with 150+ yards and three TDs in a game, joining Tyler Lockett and Steve Largent. The defense dominated the second half, limiting Arizona to four first downs and securing the victory with a 16‑play, 70‑yard drive that ended with AJ Barner's tush push. With Jadarian Price exiting due to a chest injury, Emanuel Wilson contributed 92 rushing yards. Macdonald praised both Lock and Smith-Njigba, emphasizing their chemistry and impact.

Lock's performance showcased his ability to protect the ball, being sacked only once. He expressed gratitude for the team's support and his connection with Smith-Njigba, highlighting their growing synergy. The win solidifies Seattle's early-season momentum as they prepare for an accelerated return of Darnold.