Week 1 of the 2026 NFL season opens with NFC East rivals clashing: Commanders at Eagles and Cowboys at Giants. Philadelphia, the two-time defending champion, aims for a three-peat last achieved by Andy Reid's Eagles (2001-2004). The Eagles are favorites (+122) over Cowboys (+184), Commanders (+600), and Giants (+600) per Draft Kings Sportsbook. Significant coaching changes include John Harbaugh taking over the Giants and new offensive coordinators for three teams.

Eagles QB Jalen Hurts adapts to a new scheme under coordinator Sean Mannion after the league's highest-paid offense ranked 23rd in passing last year. Hurts showed inconsistency in camp with double-digit interceptions. Cowboys QB Dak Prescott, 33, targets a fifth consecutive 4,500-yard, 30-touchdown season and hasn't missed playoffs in consecutive years as a starter. Giants second-year QB Jaxson Dart must elevate his play in Matt Nagy's system after a promising rookie campaign (15 TDs, 5 INTs, 9 rushing TDs). Commanders QB Jayden Daniels impressed in training camp with offensive coordinator David Blough noting his accuracy and command of the new offense.