Drew Mestemaker threw for 317 yards and two touchdowns while rushing for 109 yards and a score, and Oklahoma State ended a 21-game skid against FBS opponents by beating No. 6 Oregon 39-31 on Saturday in Stillwater.

Coach Eric Morris' first victory with the Cowboys came after Oklahoma State went 1-11 last season and lost to Tulsa in its opener. The Ducks, preseason No. 2, closed as 24½-point favorites at DraftKings. Oregon had won 57 consecutive games when favored by 24-plus points.

Mestemaker, one of 88 new players on the Cowboys' roster, bounced back from a poor performance in the opener. After Dante Moore's scoring pass to Evan Stewart gave Oregon a 31-30 lead early in the fourth, Mestemaker drove the Cowboys 75 yards, launching himself over defenders on a 10-yard scoring run for a 36-31 advantage.

Oregon was the second most popular bet on the board at multiple sportsbooks. The Ducks were outgained 554-281 as Oklahoma State built a 24-17 halftime lead behind 179 passing yards and two touchdown passes from Mestemaker.