Each Friday, Adam Rank provides his take on NFL developments for fantasy lineups. Baker Mayfield signed a contract extension and is a smash start against the Bengals. Patrick Mahomes is back, but Rank isn't ready to start him; the Broncos held him in check last season, and he was sacked 34 and 36 times the past two seasons. Jalen Hurts is a good start; Sean Mannion wants to reestablish the run, and Hurts averaged 21.7 fantasy points in the first eight games of 2025.

In the backfield, Bhayshul Tuten and Chris Rodriguez Jr. will split carries for Jacksonville, but both can be started against the Browns. Start both Buccaneers running backs: Bucky Irving and Kenny Gainwell. Javonte Williams has a great matchup against the Giants, who allowed the fourth-most points to running backs last season. Omarion Hampton should crush the Cardinals defense. RJ Harvey is a flex start. David Montgomery fits the Texans' style.