Both teams rebounded from Week 1 setbacks, with the Los Angeles Rams defeating the New York Giants and Denver beating Jacksonville. Matthew Stafford threw four touchdowns despite missing Puka Nacua and Myles Garrett, while Aaron Donald posted a 30% pass rush win rate. For Denver, Bo Nix led a 20-13 win.

ESPN analyst Seth Walder notes the critical matchup is the Rams offense against the Broncos defense, specifically questioning if Pat Surtain II and Riley Moss can contain Davante Adams. Walder highlights the Rams' advantage in the running game, as Denver ranks last in EPA allowed per opponent designed run. Regarding betting, Walder initially favored the 2.5-point favorite Rams but shifted after checking ESPN's Football Power Index, which favors Los Angeles by 3.9 points.

He argues the Broncos, despite a near-Super Bowl run last year, lack model respect. For player props, Walder suggests Bo Nix UNDER 17.5 rushing yards, citing limited scrambling in 2026 compared to 2025. Jaylen Waddle OVER 55.5 receiving yards is also noted as a strong play due to the Rams' man coverage lean and Waddle's speed.