Week 1 of the 2026 NFL season kicks off with the defending champion Seattle Seahawks hosting the New England Patriots in a Super Bowl rematch. The Los Angeles Rams face the San Francisco 49ers in the first international game of the year in Melbourne, Australia. Notable matchups include Buffalo at Houston, Minnesota at Green Bay, Dallas at New York on Sunday Night Football, and Kansas City at Denver on Monday Night Football.

The Los Angeles Chargers are 10‑point favorites over the Arizona Cardinals, while the Buccaneers‑Bengals game tops the week with a 50.5 total. Analysts highlight several early bets: Jacksonville’s -7.5 against Cleveland, the Falcons‑Steelers UNDER 42.5, and the Saints +7 at Detroit. Each pick is backed by recent performance trends, defensive strengths, and offensive fit, offering early value before odds shift further.