Manchester City will host Liverpool in the standout FA Cup quarterfinal tie, setting up a blockbuster clash between two Premier League giants. The draw also paired Chelsea with League One strugglers Port Vale, who pulled off a shock win over Sunderland to reach the last eight for the first time since 1954.

Port Vale's remarkable run continues despite sitting eight points adrift at the bottom of the third tier. Meanwhile, Arsenal will travel to Southampton after the Championship side edged Fulham 1-0 on an injury-time penalty from Ross Stewart. The winners of Monday's West Ham vs Brentford tie will host Leeds, who comfortably dispatched Norwich 3-0.

The quarterfinals are scheduled for the weekend of April 4, with the potential Man City-Liverpool matchup promising to be a highlight of the competition. Chelsea's 4-2 extra-time victory over 10-man Wrexham in the previous round demonstrated the unpredictable nature of the tournament, while Arsenal's progression past Mansfield showed the challenges even top-flight teams face against lower-league opposition.