Houston Texans running back Joe Mixon faces an unclear future after missing the entire 2025 season with a mysterious foot injury. General manager Nick Caserio described the issue as a "freak" medical condition that never improved, leaving the team without its 2024 leading rusher. Mixon's absence was a significant blow to the offense.

Caserio provided limited details, stating Mixon's injury was not due to irresponsible activity but a unique situation that defied typical recovery timelines. The Texans reached the divisional round for a third straight year but struggled on the ground, managing just 48 rushing yards in their playoff loss. Rookie Woody Marks and veteran Nick Chubb filled in, combining for 1,209 yards.

With one year left on his $27 million contract, Mixon's status for 2026 training camp remains unknown. The Texans' playoff hopes, buoyed by quarterback C.J. Stroud, may hinge on a healthy backfield. Caserio indicated the team will reassess Mixon's condition during the offseason before making any decisions on his role.