The Buffalo Bills travel to Denver for a divisional round matchup against a Broncos team coming off a first-round bye. Analysts see Denver's top-tier defense, which plays man coverage on a league-high 60.8% of opponent dropbacks, as a major obstacle for Josh Allen and the Bills' offense.

Denver's defensive strength creates a tough schematic challenge. Buffalo will need to get the ball out of Allen's hands quickly, likely relying on crossers and underneath throws. The Bills' run game, featuring James Cook III, remains critical, but the Broncos' ability to stop the run could force a more pass-heavy script, increasing interception risk.

On the other side, quarterback Bo Nix and the Broncos' offense face a disciplined Bills defense. Denver's offense has struggled with touchdown efficiency, punting frequently and relying on its defense to keep games close. Betting markets point to a controlled, low-scoring affair, with the total points UNDER 45.5 being a strong consideration.