The Cleveland Cavaliers face a significant setback as they head into Friday night's game against the Detroit Pistons without star guard Donovan Mitchell and All-Star forward James Harden. Mitchell is day-to-day with a right groin strain, while Harden remains sidelined indefinitely after fracturing his right thumb during Tuesday's loss to the Pistons. The absence of both players derails the momentum Cleveland had built since acquiring Harden at the trade deadline, where they went 6-1 in seven games with him in the lineup.

Harden, averaging 18.9 points and 8.0 assists on 49% shooting, was a key addition for his scoring punch and playmaking. Coach Kenny Atkinson expressed cautious optimism about Harden's thumb, noting it felt improved from previous days, but the protective brace hindered his ability to dribble and shoot effectively. Guard Keon Ellis is also out with a fractured left index finger sustained against the Bucks, and forward Dean Wade is sidelined with a sprained right ankle.

The Cavs' depth is being tested, with Atkinson acknowledging their resilience despite the injuries.