Week 6 of the 2026 college football season features a marquee matchup as No. 2 Georgia travels to Tuscaloosa to face red-hot No. 6 Alabama, with the Crimson Tide opening as 1.5-point favorites after initially being listed as three-point home underdogs. The only other ranked-vs.-ranked game is No. 21 UCLA at No. 13 Oregon, where the Ducks are favored by 11.5 points. Other notable games include No. 1 Texas (-7.5) at Oklahoma in the Cotton Bowl in Dallas, No. 7 Indiana (-7) at undefeated Nebraska, Texas A&M at No. 14 Missouri (-3.5), and No. 10 LSU (-10) at Kentucky.
Additional lines show No. 20 Iowa at Washington (-2.5), Iowa State at No. 8 BYU (-10.5), UCF at No. 18 Oklahoma State (-10), North Carolina at No. 25 Pittsburgh (-4.5), South Carolina at No. 16 Florida (-14), Stanford at No. 3 Notre Dame (-37.5), No. 9 Ole Miss at Vanderbilt (-10), and No. 22 Houston at Kansas State (-2.5). All odds are provided by DraftKings and subject to change. Times are Eastern.
Source: ESPN General · Summarized by HeadlinesBriefing