Duke, Michigan, and Arizona have separated themselves from the pack as the 2025-26 men's college basketball season reaches its final weekend. Duke Blue Devils lead the rankings at 28-2, with their average margin of victory in ACC games climbing to 24.5 points since mid-January. The Blue Devils face North Carolina in a crucial matchup that could solidify their No. 1 seed heading into the NCAA tournament.

Florida's recent dominant run has pushed the Gators into contention for a top seed, with their streak of scoring 90-plus points against ranked opponents now at six games. Meanwhile, UConn Huskies hold the inside track for the fourth 1-seed despite recent defensive struggles. The Huskies face Marquette in a pivotal Big East matchup that could determine their tournament positioning.

Conference tournaments loom large this week, with Michigan State's surge creating a potential logjam for 2-seeds. The Spartans' four-game winning streak, including road victories at Purdue and Indiana, has them squarely in the hunt for a top-four seed. Illinois Fighting Illini and Houston Cougars also jockey for position, with Houston's recent wins over Colorado and Baylor restoring order after a three-game losing streak.