Coco Gauff supports the WTA Tour's new gene-testing policy, emphasizing the need to protect fairness in women's sports. However, she expressed concern over how the discussion has become politicized, leading to "animosity towards the trans community." Gauff believes the topic warrants a more nuanced conversation, stating, "I also do not like the attack that it is creating." She noted that some individuals may exploit the policy to target transgender individuals.

The WTA's mandatory gene testing, required for competition at the 2028 Los Angeles Olympics, involves testing for the SRY gene. The association states the policy aims to distinguish between biological sex and gender identity without disrespecting any individual. This screening is already implemented in other sports like track and field, skiing, and boxing.

Gauff questioned the transparency of the policy's introduction, as some players were unaware until its public announcement. World No. 2 Elena Rybakina also commented, stating she would comply if required, though she felt the testing was not strictly necessary previously. The policy has drawn criticism from human rights experts and activist groups.