A cargo plane operated for Amazon overran a runway at Miami International Airport on Sunday afternoon, killing at least five people and injuring at least five others. The Boeing 767-300 cargo aircraft, built in 1994 and operated by 21 Air, had departed from Luis Muñoz Marín International Airport in San Juan, Puerto Rico, and touched down in Miami just before 2 p.m., according to the Federal Aviation Administration.

The plane crashed into multiple vehicles after leaving the runway. Raied Jadallah, chief of Miami-Dade Fire-Rescue, reported that several people were trapped inside their cars, with some described as "mangled." Three injured individuals were in critical condition and transported to a trauma center. Runway excursions are the most common type of aviation accident, though the cause of Sunday's crash was not immediately apparent.

The incident disrupted operations at Miami International Airport, located about 10 miles from downtown Miami and recognized as the nation's busiest for international freight. Thousands of passengers faced delays and cancellations during the busy Labor Day weekend. At least 187 flights were canceled and 266 delayed. Two of four runways reopened roughly three hours after the crash.

This marks another fatal cargo plane accident at the same airport, where a crash in August 1997 also claimed five lives.