Patrick Mahomes and the Kansas City Chiefs returned to form with a dominant victory, but the weekend was overshadowed by serious injuries to Caleb Williams and Jayden Daniels. Seattle Seahawks extended their winning streak to 12 games with a 31-7 win over the Arizona Cardinals, fueled by Drew Lock's three touchdown passes, including an 82-yard connection with Jaxon Smith-Njigba. Meanwhile, the San Francisco 49ers continued their unbeaten start, defeating the Miami Dolphins 35-15 after scoring on their first five possessions, with Christian McCaffrey and George Kittle finding the end zone.

The Cincinnati Bengals secured a 20-6 win in Houston, with Ja'Marr Chase delivering a touchdown catch contender, while a stout defense limited CJ Stroud. In a dramatic finish, the Philadelphia Eagles edged the Tennessee Titans 20-17, as Jalen Hurts threw a winning touchdown pass to Darius Cooper with just nine seconds remaining.