Julia Louis-Dreyfus, 65, will make her Broadway debut this fall in a revival of Jon Robin Baitz's "Other Desert Cities" at the Hudson Theater, marking her first stage appearance in over four decades. The actress, known for her Emmy-winning roles in "Seinfeld" and "Veep," describes the prospect as "terrifying" yet "delicious."

Louis-Dreyfus has faced significant personal challenges recently, including chemotherapy and surgery for cancer, and the loss of her Pacific Palisades home in last year's fire, prompting a move to Santa Barbara, Calif., where her husband Brad Hall grew up. Despite these hardships, she remains drawn to complex, "hungry" female characters who push against societal norms.

Her theater roots trace back to high school and Northwestern University, where she performed with a company co-founded by Hall. After a brief stint on "Saturday Night Live," she built a celebrated screen career. Now, she returns to the stage seeking the centered clarity she once found there, embracing the vulnerability of live performance after decades in television and film.