Novo Nordisk (NVO) stock plummeted over 13% in premarket trading after its experimental obesity drug, CagriSema, failed to meet a primary endpoint in a head-to-head trial against Eli Lilly's (LLY) drug. Eli Lilly shares rose 2.9% as the rival's setback provided a boost. Domino's Pizza (DPZ) surged 4.9% after beating fourth-quarter U.S. same-store sales expectations, driven by value promotions and new menu items. Netflix (NFLX) fell 0.7% following President Trump's demand that the streaming service fire board member Susan Rice or face consequences, amid DOJ review of its Warner Bros Discovery acquisition. Other movers included Merck (MRK) gaining 0.4% on a reported business split, and Alphabet (GOOGL) rising 0.3% after a Wells Fargo upgrade citing AI leadership advantages. The premarket decline followed broader U.S. futures weakness linked to renewed trade uncertainty post-Supreme Court ruling against Trump's tariffs.