The San Francisco 49ers will welcome back tight end George Kittle and defensive end Nick Bosa for their Week 1 matchup against the Los Angeles Rams. Both players were removed from the final injury report after recovering from significant setbacks. Kittle returned from a torn right Achilles tendon suffered in January, while Bosa recovered from a torn right ACL sustained in Week 3 last season.

Coach Kyle Shanahan emphasized the need to be "smart" with their workloads despite their availability. Kittle expressed excitement at being back on the field, calling it good to have a "Hall of Fame-caliber player" back. Bosa stated he is 100% ready to go with no restrictions.

On the final injury report, only defensive tackle Alfred Collins is out after tearing a patellar tendon in practice. Rookie defensive tackle James Thompson Jr. is questionable with a hamstring issue.