The San Francisco 49ers arrived in Melbourne, Australia, with defensive end Nick Bosa and tight end George Kittle as key injury concerns ahead of their Week 1 matchup against the Los Angeles Rams. Both players are expected to play in Thursday's game at the Melbourne Cricket Ground. Bosa, recovering from a torn ACL in his right knee from Week 3 last season, was confirmed by defensive coordinator Raheem Morris to be active, stating, 'Oh, he's going out there.' Offensive coordinator Klay Kubiak expressed strong confidence in Kittle's return after tearing his right Achilles in January, noting he has looked 'fresh' and is practicing at full speed.

Kubiak said Kittle 'looks good' and will likely play, with a final decision after the week's practices. Bosa had a tentative training camp due to tendinitis but returned to practice before the team's Australia trip and indicated he would play barring setbacks. The 49ers activated Kittle from the physically unable to perform list on August 24, and he has participated regularly in team drills since.