Former Senator Sherrod Brown, Democrat of Ohio, has spent over $200,000 on a 30-second advertisement responding to attacks from his Republican opponent Jon Husted and an Elon Musk-backed PAC regarding transgender issues. The ad opens with voters in Johnstown and Granville, Ohio, questioning the focus on transgender rights amid economic concerns. It features a text overlay stating "IN OHIO IT’S ILLEGAL TO PERFORM TRANSGENDER SURGERIES ON CHILDREN," referencing a 2024 Ohio law banning gender-transition medications for minors and restricting transgender athletes in school sports.

Voters across the state denounce Husted for increasing grocery costs, removing 490,000 Ohioans from health care, supporting utility bill hikes, and ignoring gas prices. The ad concludes with Brown saying, "Jon Husted, why don’t you start working for us?" While the ad accurately notes the 2024 law and Husted’s role in a 2019 energy law tied to a bribery scandal, claims about Husted voting to "increase the cost of groceries" are misleading, though tied to his support for tariffs and policies affecting prices. The health care loss estimate of 489,815 Ohioans comes from a Joint Economic Committee analysis of Medicaid and Medicare cuts.