The 2026-27 club season is just a month old, and we are already heading into an international break, but there are heavyweight clashes this weekend before the three-week break kicks in. Classic derbies, top-of-the-table matches and long-standing rivalries are ready for a new chapter across Europe.

Top two in Italy square up in heavyweight clash AS Roma vs. Internazionale Serie A, Matchday 5. Kickoff: Saturday, 12:00 p.m. ET / 5:00 p.m. BST. This is the game of the weekend in all of Europe, as it pits the early pacesetters in Italy against each other. Roma, chasing their first Scudetto since 2001, face reigning champions Inter at the Stadio Olimpico as league leaders due to their superior goal difference. Inter have won 10 and lost two of their last 12 meetings with Roma dating back to 2021. MY PREDICTION: Roma 2-1 Inter.

Madrid derby heats up title race Atlético Madrid vs. Real Madrid La Liga, Matchday 7. Kickoff: Sunday, 10:15 a.m. ET / 3:15 p.m. BST. The 244th Madrid derby is all about which team emerges as the biggest challenger to reigning champions and unbeaten La Liga leaders Barcelona. MY PREDICTION: Atleti 1-3 Real.

Can the Seagulls stop the Gunners' unbeaten run? Brighton & Hove Albion vs. Arsenal Premier League, Matchday 5. Kickoff: Saturday, 10:00 a.m ET / 3:00 p.m. BST. There is already talk in England of Arsenal going unbeaten this season.