Premier League leaders Arsenal aim to secure their Champions League quarterfinal spot when they face Bayer Leverkusen in Tuesday's crucial knockout fixture. The Gunners enter this match with momentum domestically but must navigate Leverkusen's European pedigree in their quest to advance beyond the group stage.

Chelsea returns to action looking to overturn last week's disappointing result against reigning champions Paris Saint-Germain. Manager Liam Rosenior's squad faces a daunting 5-2 deficit as they host the French champions at Stamford Bridge, needing near-perfection to keep their European hopes alive.

Manchester City faces perhaps the most challenging task of all: overcoming Real Madrid's formidable 3-0 first-leg advantage at the Etihad Stadium. Pep Guardiola's side needs a historic comeback to progress, with the Spanish giants holding a commanding position in this knockout tie that could define their season.