The NFL unveiled its 2026 slate on May 14, and sportsbooks have already posted opening lines. Wednesday’s season‑opener pits the defending champion Seattle Seahawks against the New England Patriots in a Super Bowl rematch, with Seattle listed as a 3.5‑point home favorite. The game kicks off at 8:20 p.m. ET on NBC, with a moneyline of Seahawks -192, Patriots +160 and an over/under of 44.5 points. Nine Week 1 contests carry a field‑goal spread or less.

Thursday shifts the spotlight overseas as the NFC West clash between the Los Angeles Rams, current Super Bowl favorites, and the San Francisco 49ers heads to Melbourne’s Cricket Ground. The Rams open as 2.5‑point favorites, while the Chargers become the only double‑digit favorite, listed at 11.5 points over Arizona. The Buccaneers‑Bengals game tops the week with a 50.5 total. Rams‑49ers clash airs 8:35 p.m. ET on Netflix.

Other notable lines include the Bears at Panthers (-2.5), the Lions at Saints (-7) and the Chiefs‑Broncos Monday night duel (-2.5). High‑profile holiday fixtures feature the Packers‑Rams Thanksgiving matchup and a Christmas Day showdown between the Rams and Seahawks. With odds set, fans can now gauge early value as the league builds toward a tightly contested season.