The Seattle Seahawks host the San Francisco 49ers in Saturday's NFC divisional playoff, with oddsmakers favoring Seattle by 7 points. The matchup features a stark contrast in offensive health, as the 49ers enter without star tight end George Kittle, who suffered a torn Achilles in the regular season finale. Seattle’s defense, ranked among the league’s best, aims to replicate its Week 18 performance where it limited the 49ers to just one completion over 20 yards.

Betting analysis centers on Seattle’s run game, which found success against San Francisco’s front in their last meeting. Running backs Kenneth Walker III and Zach Charbonnet both surpassed 70 rushing yards in that game, with Charbonnet’s over/under for total yards set at 61.5. Meanwhile, 49ers receiver Jauan Jennings presents a prop opportunity, needing just 40.5 receiving yards against a Seahawks defense that often plays two-deep zone coverages.

The 49ers’ offensive foundation remains Kyle Shanahan’s run game featuring Christian McCaffrey, though efficiency has waned this season. Seattle’s defensive coordinator will likely focus on containing McCaffrey’s dual-threat ability while forcing quarterback Brock Purdy to throw into tight windows without his top receiving target. For the Seahawks, offensive coordinator Klint Kubiak will continue emphasizing early-down rushing to control tempo and keep the 49ers’ offense off the field.