At the start of the 2025 season, the Buffalo Bills were Super Bowl favorites at +650 and the AFC East at -350. Those lines shifted to +400 and -2500 by Week 5, after a 23‑20 loss to the New England Patriots that nearly knocked them out of playoff contention. AксOT loss to Denver 좀 ended their run, prompting the firing of Sean McDermott and promotion of OC Joe Brady.

The Bills have posted 10+ wins for seven straight seasons and 11+ in six straight, and the 2026 schedule, the eighth‑hardest by opponents’ win percentage, still looks favorable. The offense, averaging 27.1 PPG last year, now has DJ Moore as a three‑level target for Josh Allen, while Jim Leonhard takes over defensive playcalling, promising a pressure‑heavy scheme.

With a veteran roster and a new coaching staff, the Bills are projected to surpass their 12‑5 record, with bettors targeting an over of 11.5 wins (+154). The momentum points toward a return to AFC East dominance and a Super Bowl bid.

The analysis highlights why Buffalo remains a top contender for 2026, as the team balances offensive firepower with a revamped defense under its new leaders.