Howard 74, Ohio State 67 - Howard's defense stifles Ohio State's offense, with Tasha Smith scoring 22 points to lead the Bulldogs past the Buckeyes. Meanwhile, Vermont 76, Louisville 68 sees Kaitlin Shea's 23-point explosion propel the Catamounts past the Cardinals. Southern 68, South Carolina 64 marks Jahjah Williams' clutch 14-point, 10-rebound performance as the Gamecocks edge the Gamecocks. Fairleigh Dickinson 73, Iowa 71 showcases Kaitlyn Jones' 18-point, 15-rebound double-double in a thrilling upset. Princeton 75, Oklahoma State 72 features Jordan Matthews' 24-point game to cap a comeback. These results shift the NCAA Women's Tournament landscape significantly, with top seeds like Ohio State and Louisville exiting early. The NCAA Women's Tournament now heads toward the Sweet 16 with new contenders emerging.

Virginia 67, Georgia 63 highlights Sarah Fuller's 21-point, 8-assist effort as the Cavaliers advance. USC 75, Clemson 72 features A'ja Wilson's 31-point, 8-rebound masterpiece for the Trojans, while Miami (OH) 74, West Virginia 71 sees D'Mitrice Richardson's 28-point, 12-rebound performance propel the RedHawks. These games demonstrate the NCAA Women's Tournament's depth, with mid-major teams like Fairleigh Dickinson and Princeton proving they belong with the elite. The NCAA Women's Tournament field now features fewer top-10 teams than in previous years, creating opportunities for underdogs. USC's victory over Clemson, a top-5 seed, stands as the biggest upset of the round.

Fairleigh Dickinson's win over Iowa and Princeton's comeback against Oklahoma State signal a NCAA Women's Tournament shift toward unpredictability. The NCAA Women's Tournament bracket now includes more first-round upsets than any season in recent memory, with only 4 of 16 top-5 seeds advancing. USC's dominance under Wilson and Fairleigh Dickinson's defense suggest these teams could challenge for the title. The NCAA Women's Tournament landscape has fundamentally changed, with traditional powers now facing steeper challenges than ever before.