UConn opens as the 54.5-point favorite against UTSA in the first-round of the 2026 women's tournament, while UCLA is a 49.5-point favorite against California Baptist, according to ESPN's latest odds. The brackets and game lines for the round of 64 have been released, kicking off action at 11:30 a.m. ET. ESPN's betting lines, sourced from DraftKings Sportsbook, show Duke as a 33.5-point favorite over Charleston with a BPI projection of a 26-point win, while TCU is favored by 27.4 points against UC San Diego.

The projections highlight the significant gaps between top seeds and lower-ranked teams.