The NFL's opening Sunday set a record for most points scored on a season-opening weekend since the 1970 merger. The Buffalo Bills edged the Houston Texans 36-31 as Josh Allen threw for 334 yards and four touchdowns in Joe Brady's debut as head coach. Allen clinched the win with a 34-yard pass to Joshua Palmer late in the fourth quarter.

The Baltimore Ravens dominated the Indianapolis Colts 41-23 under new coach Jesse Minter. Zay Flowers posted a career-high 150 receiving yards and a touchdown in the first half, while Derrick Henry scored three times to move third all-time in rushing touchdowns. Flowers and rookie Ja'Kobi Lane left with hamstring and wrist injuries.

The Chicago Bears crushed the Carolina Panthers 59-37, the highest-scoring Week 1 game ever and Chicago's most points since 1980. Caleb Williams threw for 269 yards, and D'Andre Swift scored three touchdowns. Coach Ben Johnson declared ambitions for the highest scoring offense and Super Bowl titles.

The New York Giants beat the Dallas Cowboys 28-20 in John Harbaugh's debut. Jaxson Dart threw three touchdowns, and Cam Skattebo added a rushing score. The game featured tributes marking the 25th anniversary of 9/11 at MetLife Stadium.