England will start their Six Nations campaign against Wales without captain Maro Itoje on the field, marking his first absence in nearly seven years. Itoje, who missed pre-tournament preparations to attend his mother's funeral, will be on the bench, with Jamie George leading the team from the start. This decision comes as a strategic move by coach Steve Borthwick, aiming to balance the team's experience and fresh talent.

The selection of Northampton's Fraser Dingwall and Tommy Freeman in midfield is a significant shift, signaling a new phase in England's backline strategy. Dingwall and Freeman, who have shown promise in recent games, will be crucial in executing Borthwick's tactical plans. Their inclusion reflects a growing focus on domestic form, with their performances at Northampton likely influencing this decision.

Looking ahead, England's bench lacks the depth of experienced replacements seen in the autumn series. With key props and back-row players starting, the team's ability to maintain intensity throughout the match will be tested. This match-up against Wales, known for their aerial prowess, will be a litmus test for Borthwick's strategic adjustments and the new midfield pairing's effectiveness.

The absence of Will Stuart and Fin Baxter due to injuries further complicates England's front row. With fewer experienced replacements, the onus is on the starting lineup to deliver a strong performance. This match against Wales is not just about securing a win but also about establishing a foundation for the rest of the Six Nations campaign.