West Bromwich Albion faces a historic low, having lost 10 consecutive away league games. New manager Eric Ramsay's first away trip is to Derby County, where another defeat would equal a 135-year-old club record for the worst away run. Their last away league point came on 1 October.

Two long-awaited south coast derbies headline the fixtures. Portsmouth host Southampton for the first time in a league match since 2011, with both clubs struggling for form. Meanwhile, Millwall and Charlton Athletic renew a fierce rivalry at The Den after a five-year gap.

In League One, Mansfield Town has surged into play-off contention with four straight wins. New Huddersfield Town boss Liam Manning faces an immediate test against high-flying Bradford City. In League Two, leaders Bromley face a direct challenge from second-placed Swindon Town in a top-of-the-table clash.